KDM4D MUTANT MICE SHOW IMPAIRED SPERM MOTILITY AND SUBFERTILITY

Kdm4d mutant mice show impaired sperm motility and subfertility

Regulation of gene expression through histone modifications underlies cell homeostasis and differentiation.Kdm4d and Kdm4dl exhibit a high degree of similarity and demethylate H3K9me3.However, the physiological functions of these proteins remain unclear.In this study, we generated Kdm4dl mutant mice and found that Kdm4dl was dispensable for mouse d

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Investigation of civil responsibility for the spread of environmental pollution caused by the Coronavirus pandemic

The most important objectives of the present study include finding a legal solution to prevent the spread of coronavirus, compensation for damages caused by the negligence of human factors, determining the basis for this responsibility, and the rate of compensation for these damages.The present study, through library and field studies, made it poss

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10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents

10H-1,9-diazaphenothiazine was obtained in the sulphurisation reaction of diphenylamine with elemental sulphur and transformed into new 10-substituted derivatives, containing alkyl and dialkylaminoalkyl groups at the thiazine nitrogen atom.The 1,9-diazaphenothiazine ring system was identified with advanced 1H and 13C Candle NMR techniques (COSY, NO

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